N-trifluoroacetyl derivatives as pharmacological agents. IV--Antiinflammatory and related properties; antimicrobial activity of some polyaromatic trifluoroacetamides
Vigorita, M.G.; Previtera, T.; Trovato, A.; Monforte, M.T.; Barbera, R.; Bisignano, G.
Farmaco 44(2): 173-184
1989
ISSN/ISBN: 0014-827X PMID: 2775414 Document Number: 345979
Taking into account both the analogy with the antiinflammatory triflamides and our previous observations on a series of trifluoroacetanilides active as acute and chronic antiinflammatory agents, the present series of polyaromatic N-trifluoroacetylderivatives were prepared. Their antiinflammatory and related properties as well as antimicrobial activity were evaluated. Few derivatives were found to display significant analgesic effects (hot plate test) whereas at 50 mg/kg all were devoid of antiinflammatory effects except the benzophenone derivative (III). Instead as regards the antimicrobial screening, a selective antimycoplasmal activity was revealed in six out of ten examined compounds.