Top Abstract Purchase Related
Home
>
Node
>
Subnode

Aminopyrazinyl derivatives: synthesis and evaluation of antiinflammatory and related activities

Vigorita, M.G.; Grasso, S.; Zappalà, M.; Ottanà, R.; Monforte, M.T.; Barbera, R.; Trovato, A.

Farmaco 49(4): 271-276

1994

ISSN/ISBN: 0014-827X
PMID: 8049007
Document Number: 437257
Some amides, 1-substituted methylenediamines and 2-substituted thiazolidin-4-ones, all containing the aminopyrazinyl moiety, were synthesized and tested in the experimental models of acute and chronic inflammations and as potential analgesic agents. The first series of compounds are inactive, whereas the N,N'-di-(2-pyrazinyl)-methylene-diamines and the 3-(2'-pyrazinyl)-thiazolidinones 6, 7, 11, 12 and even more 16 and 17 were found to be endowed with antiinflammatory and analgesic properties and low acute toxicity, the two latter being the most interesting.

Document emailed within 1 workday
Secure & encrypted payments

Savini, L.; Massarelli, P.; Pellerano, C.; Bruni, G. 1993: New quinoline derivatives: synthesis and evaluation for antiinflammatory and analgesic properties--Note II Farmaco 48(6): 805-825
Passarotti, C.M.; Valenti, M.; Marini, M. 1995: In the search for new antiinflammatory drugs: synthesis and antiinflammatory activity of some Thiazolo(3,2-a)pyrimidine derivatives containing a thioether group Bollettino Chimico Farmaceutico 134(11): 639-643
Da Settimo, A.; Primofiore, G.; Da Settimo, F.; Marini, A.M. 1992: Synthesis and antiinflammatory properties of 2-aminobenzimidazole derivatives Farmaco 47(10): 1293-1313
Bartoń, H. 1979: Synthesis of new benzophenone derivatives with potential antiinflammatory activity Polish Journal of Pharmacology and Pharmacy 31(2): 169-174
Odasso, G.; Winters, G.; Schiatti, P.; Selva, D. 1983: Cyclic hydrazides. V - synthesis and antiinflammatory activity of derivatives of the 2-amino-1,4-dihydroisoquinolin-3(2H)-one Il Farmaco; Edizione Scientifica 28(3): 199-204
Kuźmierkiewicz, W.; Foks, H.; Hać, E.; Strzałkowska-Grad, H. 1985: Synthesis and analgetic and antiinflammatory activity of derivatives of 3-(1H-benzimidazole-2)propanoic acid Die Pharmazie 40(7): 462-464
Naik, P.R.; Pandeya, S.N. 1994: Synthesis, antiinflammatory and analgesic activities of some 1,2,4-thiadiazolidines and 1-4-aryl guanidines Bollettino Chimico Farmaceutico 133(5): 289-293
Abignente, E.; Arena, F.; De Caprariis, P.; Nuzzetti, R.; Marmo, E.; Lampa, E.; Rosatti, E.; Ottavo, R. 1981: Research on heterocyclic compounds. X.-Imidazo[1,2-a]pyrazine derivatives: synthesis and antiinflammatory activity Il Farmaco; Edizione Scientifica 36(1): 61-80
Vigorita, M.G.; Previtera, T.; Trovato, A.; Monforte, M.T.; Barbera, R.; Bisignano, G. 1989: N-trifluoroacetyl derivatives as pharmacological agents. IV--Antiinflammatory and related properties; antimicrobial activity of some polyaromatic trifluoroacetamides Farmaco 44(2): 173-184
Bonina, F.; Guerrera, F.; Sarvà, M.C.; Siracusa, M.A.; Caruso, A.; Leone, M.G.; Amico Roxas, M. 1987: Synthesis and analgesic antiinflammatory activities of 2-aryl-ethenyl-4-aryl-thiazole-5-acetic acids Il Farmaco; Edizione Scientifica 42(12): 905-913
Kojima, E.; Ohta, K.; Miyawaki, S.; Date, T.; Machida, M.; Murakami, K. 1995: Synthesis and antiviral activities of 9-cyclopentylpurine derivatives Nucleic Acids Symposium Series 34: 107-108
Lu, J.M.; Zhang, Y.I.; Yan, M.; Lei, X.H. 1984: Synthesis and biological activities of some new 3-methyl-5-nitrofuran derivatives Yao Xue Xue Bao 19(9): 660-666
Ikizler, A.A.; Demirbas, A.; Johansson, C.B.; Celik, C.; Serdar, M.; Yuksek, H. 1998: Synthesis and biological activities of some 4,5-dihydro-1H-1,2,4-triazol-5-one derivatives Acta Poloniae Pharmaceutica 55(2): 117-123
Basoglu, S.; Yolal, M.; Demirci, S.; Demirbas, N.; Bektas, H.; Karaoglu, S.A. 2013: Design, synthesis and antimicrobial activities of some azole derivatives Acta Poloniae Pharmaceutica 70(2): 229-236
Zhao, S.-y.; Huang, W.-l.; Zhang, H.-b. 2002: Synthesis and vasorelaxant activities of benzopyran-4-one hydrazone derivatives Yao Xue Xue Bao 37(8): 621-625
Saczewski, F.; Nasal, A. 1995: Synthesis and biological activities of some 7,8-dihydroimidazo[1,2-a]-1,3,5-triazine derivatives Acta Poloniae Pharmaceutica 52(3): 237-240
el-Shaaer, H.M.; Abdel-Aziz, S.A.; Allimony, H.A.; Ali, U.F.; Abdel-Rahman, R.M. 1997: Synthesis and antimicrobial activities of some new 2-substituted benzoxazole/benzothiazole derivatives Die Pharmazie 52(8): 585-589
Maeda, M.; Kaneko, C.; Uchida, N.A.; Sasaki, T. 1985: Synthesis of 1-beta-D-ribofuranosyl-1,2-dihydropyrimidin-2-one derivatives and their biological activities Nucleic Acids Symposium Series 16: 77-80
Ozkanli, F.; Dalkara, S.; Caliş, U.; Willke, A. 1994: Synthesis of some N-arylazole acetamide derivatives and their anticonvulsant and antimicrobial activities Arzneimittel-Forschung 44(8): 920-924
Zhang, Z-guo.; Zhang, Y-hua.; Ji, H.; Qiu, S-gan.; Feng, X-chun. 2004: Design, synthesis and antiasthmatic activities of NO-donating seratrodast derivatives Yao Xue Xue Bao 39(9): 705-710