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Synthesis of 1-beta-D-ribofuranosyl-1,2-dihydropyrimidin-2-one derivatives and their biological activities

Maeda, M.; Kaneko, C.; Uchida, N.A.; Sasaki, T.

Nucleic Acids Symposium Series 16: 77-80

1985

ISSN/ISBN: 0261-3166
PMID: 4088888
Document Number: 260231
Several alkyl substituted 1-beta-D-ribofuranosyl-1,2-dihydropyrimidin-2-one derivatives were synthesized by the method of stannic chloride-catalyzed glycosidation method to elucidate their inhibitory activity of cytidine deaminase and also their antitumor activities in vitro and in vivo. Alkyl substitution at position 4 or 6 of the derivatives decreased their inhibitory activity for cytidine deaminase and also decreased antitumor activity against L1210 cells in vitro.

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