Synthesis, antiinflammatory and analgesic activities of some 1,2,4-thiadiazolidines and 1-4-aryl guanidines
Naik, P.R.; Pandeya, S.N.
Bollettino Chimico Farmaceutico 133(5): 289-293
1994
ISSN/ISBN: 0006-6648 PMID: 8068236 Document Number: 424399
A series of 2,4-dimethyl-3,5-diarylimino-1,2,4-thiadiazolidines (1a-1) and 1-[2-(substituted benzothiazolyl]-1,3-dimethyl-4-aryl guanidines (2a-1) were evaluated for their anti-inflammatory and analgesic activities. Substitution of p-methoxy group (1c and 2c) in the aryl ring resulted in most active compounds in the series in both the activities and were also statistically equipotent than the standard drugs.
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