Analgesic, antiinflammatory and CNS depressant activities of sesquiterpenes and a flavonoid glycoside from Polygonum viscosum
Datta, B.K.; Datta, S.K.; Chowdhury, M.M.; Khan, T.H.; Kundu, J.K.; Rashid, M.A.; Nahar, L.; Sarker, S.D.
Die Pharmazie 59(3): 222-225
2004
ISSN/ISBN: 0031-7144 PMID: 15074598 Document Number: 578231
Analgesic, antiinflammatory and central nervous system (CNS) depressant activities of four sesquiterpenes, viscosumic acid, viscozulenic acid, viscoazucine and viscoazulone, and a flavonoid glycoside, quercetin-3-O-(6"-feruloyl)- beta -D-galactopyranoside, isolated form the aerial parts of P. viscosum (Polygonaceae) have been assessed. All test compounds exhibited CNS depressant activity in open field test. All but viscoazulone showed analgesic activity in Eddy's hot plate test. All sesquiterpenes inhibited acetic acid-induced abdominal writhing in mice, and all but viscoazucine and the flavonoid glycoside exhibited mild to moderate antiinflammatory effect on carrageenan-induced rat paw oedema.