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New quinoline derivatives: synthesis and evaluation for antiinflammatory and analgesic properties--Note II

Savini, L.; Massarelli, P.; Pellerano, C.; Bruni, G.

Farmaco 48(6): 805-825

1993

ISSN/ISBN: 0014-827X
PMID: 8373505
Document Number: 415792
The synthesis of new halogenated series of 4-anilinoquinoline-3-carboxylic acids, N-[3-carboxyquinolyl(4)]anthranilic acids and their corresponding esters is reported. These have been obtained by reacting 4-chloro-3-carbethoxy-quinolines with variously substituted anilines and methyl anthranilate respectively. The synthesized compounds were tested for antiinflammatory and analgesic activities; some of them showed a good analgesic activity, sometimes higher than that of indomethacin, used as reference drug.

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