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1H-pyrrolo[2,3-f]quinoline and isoquinoline derivatives: synthesis and antiproliferative activity

Ferlin, M.G.; Chiarelotto, G.; Basadonna, O.; Gia, O.; Mobilio, S.; Baccichetti, F.; Carlassare, F.

Farmaco 44(12): 1141-1155

1989

ISSN/ISBN: 0014-827X
PMID: 2634405
Document Number: 332314
Fischer indol synthesis is reported for the preparation of some 2-substituted 1H-pyrrolo[2,3-f]quinoline and isoquinoline derivatives having a structural correlation with naturally occurring compound ellipticine. The prepared compounds proved capable of forming in vitro molecular complexes with native double-stranded DNA by intercalation between two base pairs and showed a relatively good activity in inhibiting the DNA synthesis in Ehrlich ascites tumor cells.

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