Synthesis and antiproliferative activity of 2-triazenothiophenes
Diana, P.; Barraja, P.; Lauria, A.; Almerico, A.M.; Cirrincione, G.; Minnei, C.; Longu, S.; Congiu, D.; Musiu, C.; La Colla, P.
Anticancer Research 19(3a): 2127-2131
1999
ISSN/ISBN: 0250-7005 PMID: 10470160 Document Number: 500192
A series of 2-triazenothiophene derivatives was prepared and tested to evaluate their biological activity. Two compounds inhibited the proliferation of leukemia, lymphoma and solid tumor-derived cell lines at micromolar concentrations, whereas none of the compounds were active against HIV-1. Compound 3c inhibited DNA, RNA and protein synthesis, and was also effective against KB cells resistant to etoposide and vincristine. The compounds were inactive against fungi and bacteria.