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Novel Ru (III) , Rh (III) , Pd (II) and Pt (II) complexes with ligands incorporating azole and pyrimidine rings. I. Antiproliferative activity in vitro

Wiśniewski, M.Z.; Wietrzyk, J.; Opolski, A.

Archivum Immunologiae et Therapiae Experimentalis 48(1): 51-55

2000

ISSN/ISBN: 0004-069X
PMID: 10722233
Document Number: 524465
A number of co-ordination compounds of Ru(III), Rh(III), Pd(II) and Pt(II) with ligands incorporating azole and pyrimidine rings has been synthesized. The in vitro cell proliferation-inhibitory activity of these compounds was examined against human cancer cell lines: A 549 (lung carcinoma), LS-180 (colon cancer) and MCF-7 (breast cancer), using SRB technique. Six out of 13 compounds studied revealed cytotoxic activity in vitro. Inhibitory dose 50% (ID50) was lower than 4 mug/ml, which is an activity criterion accepted in conventional in vitro cytotoxic screening tests. Two compounds revealed weak cytotoxic activity with ID50 higher than 4 mug/ml and five compounds were inactive.

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