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Effect of inhibitors that destroy cytoskeleton structures on the antiviral and antiproliferative activity of interferons

Solov'eva, M.F.; Krispin, T.I.; Shloma, D.V.; Kalmakhelidze, K.A.; Balandin, I.G.

Voprosy Virusologii 33(3): 309-314

1988

ISSN/ISBN: 0507-4088
PMID: 2459850
Document Number: 324562
The effect of a number of drugs (vincristine, vinblastine, cytochalasin B, colcemid, colchamine) destroying cytoskeleton structures (microtubules and microfilaments) in combination with homologous interferon was studied in L920 and CaOv cells. The above substances were shown to inhibit the antiviral and enhance (from additivity to synergism) the antiproliferative effect of interferons under study.

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