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Analgesic and antiinflammatory activity screening of 6-acyl-3-piperidinomethyl-2 (3H) -benzoxazolone derivatives

Erol, D.D.; Demirdamar, R.

Farmaco 49(10): 663-666

1994

ISSN/ISBN: 0014-827X
PMID: 7826474
Document Number: 436684
6-Acyl-2(3H)-benzoxazolone derivatives were reacted with appropriate piperidine derivatives and formaldehyde in methanol to give the corresponding 6-acyl-3-piperidinomethyl-2(3H)-benzoxazolones. The obtained compounds were screened for their analgesic and antiinflammatory activities. Analgesic activity of these compounds was investigated by modified Koster test. Antiinflammatory activity was assayed by using carrageenan induced mouse paw edema test and arachidonic acid edema. The 15 compounds synthesized showed good analgesic activities; compounds 1,3 and 6 moved to be active inhibitors of edema.

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Mincheva, Z.P.; Kalcheva, V.B.; Golovinsky, E.G.; Tabakova, S.V. 1993: Synthesis and in vitro activity of new cephem derivatives with benzoxazolone ring Die Pharmazie 48(11): 859-860
Nikolova, M.; Fajad, K.; Natova, L. 1993: Synthesis and pharmacological screening of a group of piperazine derivatives. Analgesic activity Farmaco 48(4): 459-472
Passarotti, C.M.; Valenti, M.; Marini, M. 1995: In the search for new antiinflammatory drugs: synthesis and antiinflammatory activity of some Thiazolo(3,2-a)pyrimidine derivatives containing a thioether group Bollettino Chimico Farmaceutico 134(11): 639-643
Savini, L.; Massarelli, P.; Pellerano, C.; Bruni, G. 1993: New quinoline derivatives: synthesis and evaluation for antiinflammatory and analgesic properties--Note II Farmaco 48(6): 805-825
Tanaka, K.; Shimotori, T.; Makino, S.; Aikawa, Y.; Inaba, T.; Yoshida, C.; Takano, S. 1992: Pharmacological studies of the new antiinflammatory agent 3-formylamino-7-methylsulfonylamino-6-phenoxy-4H-1-benzopyran-4-o ne. 1st communication: antiinflammatory, analgesic and other related properties Arzneimittel-Forschung 42(7): 935-944
Maoret, T.; Zagnoli, G. 1984: Antiinflammatory activity and kinetics of antipyretic and analgesic effects of the sodium salt of indoprofen betainate Bollettino Chimico Farmaceutico 123(11): 521-529
Bartoń, H. 1979: Synthesis of new benzophenone derivatives with potential antiinflammatory activity Polish Journal of Pharmacology and Pharmacy 31(2): 169-174
Odasso, G.; Winters, G.; Schiatti, P.; Selva, D. 1983: Cyclic hydrazides. V - synthesis and antiinflammatory activity of derivatives of the 2-amino-1,4-dihydroisoquinolin-3(2H)-one Il Farmaco; Edizione Scientifica 28(3): 199-204
Kuźmierkiewicz, W.; Foks, H.; Hać, E.; Strzałkowska-Grad, H. 1985: Synthesis and analgetic and antiinflammatory activity of derivatives of 3-(1H-benzimidazole-2)propanoic acid Die Pharmazie 40(7): 462-464
Bartsch, H.; Malaveille, C.; Stich, H.F.; Miller, E.C.; Miller, J.A. 1977: Comparative electrophilicity, mutagenicity, DNA repair induction activity, and carcinogenicity of some N- and O-acyl derivatives of N-hydroxy-2-aminoflourene Cancer Research 37(5): 1461-1467
Abignente, E.; Arena, F.; De Caprariis, P.; Nuzzetti, R.; Marmo, E.; Lampa, E.; Rosatti, E.; Ottavo, R. 1981: Research on heterocyclic compounds. X.-Imidazo[1,2-a]pyrazine derivatives: synthesis and antiinflammatory activity Il Farmaco; Edizione Scientifica 36(1): 61-80
Abignente, E.; De Caprariis, P.; Luraschi, E.; Marmo, E.; Berrino, L.; Lo Sasso, C. 1989: Research on heterocyclic compounds. XXV. Phenyl derivatives of fused imidazole systems: antiinflammatory activity Research Communications in Chemical Pathology and Pharmacology 65(1): 35-56
Kohashi, O.; Kohashi, Y.; Shigematsu, N.; Ozawa, A.; Kotani, S. 1986: Acute and chronic polyarthritis induced by an aqueous form of 6-O-acyl and N-acyl derivatives of N-acetylmuramyl-L-alanyl-D-isoglutamine in euthymic rats and athymic nude rats Laboratory Investigation; a Journal of Technical Methods and Pathology 55(3): 337-346
Vigorita, M.G.; Previtera, T.; Trovato, A.; Monforte, M.T.; Barbera, R.; Bisignano, G. 1989: N-trifluoroacetyl derivatives as pharmacological agents. IV--Antiinflammatory and related properties; antimicrobial activity of some polyaromatic trifluoroacetamides Farmaco 44(2): 173-184
Picciòla, G.; Ravenna, F.; Carenini, G.; Manzardo, S.; Gentili, P. 1981: Heterocyclic compounds containing a 4-aminophenylalkanoic acid group with potential antiinflammatory activity. II. 2-Substituted morpholine derivatives Il Farmaco; Edizione Scientifica 36(1): 47-60
Sushma, M.; Sudha, S.; Shivamurthy, N.; Venkataraman, B.V. 2004: Analgesic activity of new synthetic thiazolidine-4-ones derivatives Indian Journal of Experimental Biology 42(8): 812-815
Jahan, S.; Akhtar, S.; Kamil, A.; Mushtaq, N.; Saify, Z.S.; Arif, M. 2016: Analgesic activity of alkyl piperidine derivatives Pakistan Journal of Pharmaceutical Sciences 29(1): 77-82
al-Deeb, O.A. 1994: Synthesis and analgesic activity of new phencyclidine derivatives Arzneimittel-Forschung 44(10): 1141-1144
Hishmat, O.H.; Hashim, A.A.; Shalash, M.R.; Nawito, M. 1972: Some benzofuran-carboxamide derivatives with narcotic and analgesic activity Arzneimittel-Forschung 22(1): 158-160
Mulé, A.; Pirisino, G.; Manca, P.; Satta, M.; Peana, A.; Savelli, F. 1988: Tert-aminoalkyl derivatives of quinoxalinones, aza- and diazaquinoxalinones with analgesic activity Il Farmaco; Edizione Scientifica 43(7-8): 613-618