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Analgesic activity of alkyl piperidine derivatives

Jahan, S.; Akhtar, S.; Kamil, A.; Mushtaq, N.; Saify, Z.S.; Arif, M.

Pakistan Journal of Pharmaceutical Sciences 29(1): 77-82

2016

ISSN/ISBN: 1011-601X
PMID: 26826841
Document Number: 686360
Piperidine is the most significant scaffold which reveals therapeutic potential because of its conformationally flexible nature. During the course of present investigations synthetic quaternary salts of alkyl piperidine with various phenacyl bromides were explored for their possible analgesic activity. Compounds I analogs (1a-1f) and compound II analogs (IIa-IIf) showed varying degree of analgesic activity when compared with pethidine as standard and its duration by tail immersion method.

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