Tert-aminoalkyl derivatives of quinoxalinones, aza- and diazaquinoxalinones with analgesic activity
Mulé, A.; Pirisino, G.; Manca, P.; Satta, M.; Peana, A.; Savelli, F.
Il Farmaco; Edizione Scientifica 43(7-8): 613-618
1988
ISSN/ISBN: 0430-0920 PMID: 3224708 Document Number: 318550
A series of tert-aminoalkyl-derivatives of quinoxalin-2-one, aza- and diazaquinoxalin-2-one bearing in position 3 a benzyl group was prepared in order to compare with analogous 3-methyl derivatives as regards analgesic activity. The substitution causes various effects. In compounds (I) and (VI-IX) is found the expected increase in analgesic activity but with contemporaneous rise in toxicity. The compounds (IV) and (V) are of interest due to the presence of a strong separation of DL50 from DE50.