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1-Phenyl-1H-indazole derivatives with analgesic and anti-inflammatory activities

Mosti, L.; Sansebastiano, L.; Fossa, P.; Schenone, P.; Mattioli, F.

Farmaco 47(3): 357-365

1992

ISSN/ISBN: 0014-827X
PMID: 1503599
Document Number: 389907
The synthesis of 4-hydroxy-1-phenyl-1H-indazole-5-acetic acid 5 4-methoxy-1-phenyl-1H-indazole-5-yl-acetic acid 7 and 5-benzyl-1-phenyl-1H-indazol-4-ol 8, starting from 1,5,6,7-tetrahydro-1-phenyl-4H-indazol-4-one, is described. These compounds showed in mice an analgesic activity superior to that of acetylsalicylic acid and comparable to that of dipyrone; moreover, compound 5 exhibited an appreciable anti-inflammatory activity in rats. Gross behavioral effects and acute toxicity in mice are also reported.

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