Some new benzoxazolinone derivatives with analgesic and anti-inflammatory activities
Pilli, G.; Erdoğan, H.; Sunal, R.
Arzneimittel-Forschung 43(12): 1351-1354
1993
ISSN/ISBN: 0004-4172 PMID: 8141825 Document Number: 421136
Fourteen new 6-acyl-2-benzoxazolinone, ethyl-(6-acyl-2-benzoxazolinone) acetate and (6-acyl-2-benzoxazolinone-3-yl) acetic acid derivatives were synthesized, and their physical properties and UV absorption data were determined. Their chemical structures were elucidated by IR, 1H-NMR and elemental analysis. The analgesic activities of these compounds were investigated by a modified Koster's test. It was shown that the respective activities of compounds 1-4 and 10-14 were higher than that of acetylsalicylic acid. Therefore, they were screened for additionally anti-inflammatory activities using the carrageenan mouse paw edema test. The compounds were further screened for their ability to inhibit prostaglandin E-2 (PGE-2) induced paw edema and compared to indomethacin. Compounds 12 and 13 were very potent in inhibiting PGE-2 induced edema.