Analgesic and anti-inflammatory effects and toxicity of houjianxi
Li, M.; Zhou, J.; Fan, Y.; Li, W.; Qin, L.; Yang, W.
Zhongguo Zhong Yao Za Zhi 15(4): 235-238; 256
1990
ISSN/ISBN: 1001-5302 PMID: 2206377 Document Number: 350093
It is effective for acute and chronic laryngopharyngitis clinically. Houjianxi can raise the pain thresholds during hot-plate test in mice, tail flick test in rats, and writhing test in mice with single dose ig 0.125 to 2.0 g/kg. Houjianxi can also inhibit the swelling of hind paw induced by sc 1% carrageenin 0.1 ml in rats as well as the increased vascular permeability induced by ip 0.7% HAC in mice. Toxic side effects were not observed for Houjianxi ig 48 g/kg x 3 within a day in mice and 1.8 g/kg daily for 90 d in rats.