Top Abstract Purchase Related
Home
>
Node
>
Subnode

Anti-inflammatory and analgesic actions of of long-chain phenyl substituted alpha-aminoketones

Schulz, E.; Frahm, C.; Kobow, M.; Sprung, W.D.

Die Pharmazie 51(8): 591-593

1996

ISSN/ISBN: 0031-7144
PMID: 8975252
Document Number: 457038
The investigated phenyl substituted alpha-amino ketones have anti-inflammatory and analgesic activities as could be shown in animal models (rats and mice). The effectiveness depends on the length of the alkyl chain. After i.p. application the most active amino ketones are ten times more effective than acetyl salicylic acid, but the activity did not reach that of indomethacin. The effective analgesic dose is ten times lower than that for anti-inflammatory action. Including the results of the toxicity the analgesic efficiency of the amino ketones could be lead to substances with high analgesic activity. After oral administration only in high doses anti-inflammatory and analgesic effectivities were found. The structural analog keto group instead of the ester or amid group leads not to the expected increase in p.o. effectivity.

Document emailed within 1 workday
Secure & encrypted payments

Bahekar, S.S.; Shinde, D.B. 2003: Synthesis and anti-inflammatory activity of some [2-amino-6-(4-substituted aryl)-4-(4-substituted phenyl)-1,6-dihydropyrimidine-5-yl]-acetic acid derivatives Acta Pharmaceutica 53(3): 223-229
Mosti, L.; Sansebastiano, L.; Fossa, P.; Schenone, P.; Mattioli, F. 1992: 1-Phenyl-1H-indazole derivatives with analgesic and anti-inflammatory activities Farmaco 47(3): 357-365
Nargund, L.V.; Redd, G.R.; Hariprasad, V. 1993: Inhibition of albumin denaturation and anti-inflammatory activity of acetamido [(phenyl-4'-yl)-oxymethyl)]2-(p-substituted phenylamino)-1,2,4-triazoles and -1,3,4-thiadiazoles Indian Journal of Experimental Biology 31(4): 395-396
Mavel, S.; Rubat, C.; Coudert, P.; Privat, A.M.; Couquelet, J.; Tronche, P.; Bastide, P. 1993: Synthesis of new 5-substituted pyrazolo[1,5-d][1,2,4]-triazine derivatives and their analgesic, anti-inflammatory and antipyretic properties Arzneimittel-Forschung 43(4): 464-468
Ao, G.-z.; Zhang, Y.-h.; Ji, H.; Deng, G. 2003: Synthesis and anti-inflammatory activity of alpha-substituted p-(methanesulfonyl)phenylpropenamides Yao Xue Xue Bao 38(9): 671-676
Islam, M.; Siddiqui, A.A. 2010: Synthesis, antituberculostatic, antifungal and antibacterial activities of 3-substituted phenyl-6-substituted phenyl-1,2,4-triazolo[4,3-b]pyridazines Acta Poloniae Pharmaceutica 67(5): 555-562
Li, R.L.; Zhang, W.S.; Wang, J.C.; Poe, M. 1987: Structure-activity relationships of the inhibition of Escherichia coli dihydrofolate reductase (MB1428) by 5-(substituted phenyl) thio and 5-(substituted phenyl) seleno-2,4-diaminopyrimidines Yao Xue Xue Bao 22(3): 233-237
Chasseaud, L.F.; Fry, B.J.; Valzelli, G.; Tosolini, G.P. 1974: Metabolic fate of the anti-inflammatory agent alpha-(4-(1-oxo-2-isoindolinyl)-phenyl)-propionic acid (K 4277) in the rhesus monkey Arzneimittel-Forschung 24(10): 1606-1609
Nakamura, H.; Kadokawa, T.; Nakatsuji, K.; Nakamura, K. 1970: Pharmacological studies of a new anti-inflammatory drug, 1-phenylsulfonyl-5,5-diphenylhydantoin (PC-796) in experimental animals. I. Anti-inflammatory, analgesic and anti-pyretic activity Arzneimittel-Forschung 20(8): 1032-1046
Diurno, M.V.; Cristinziano, A.; Mazzoni, O.; Piscopo, E.; Bolognese, A. 1995: Synthesis and antimicrobial activity of 1-(p-substituted)phenyl-3-(p-alkoxy)phenyl-4-phenyl-azetidin-2-ones Farmaco 50(2): 143-148
Ali, M.A.; Ismail, R.; Choon, T.S.; Yoon, Y.K.; Wei, A.C.; Pandian, S.; Samy, J.G.; De Clercq, E.; Pannecouque, C. 2011: Synthesis and anti-HIV activity of novel 3-substituted phenyl-6,7-dimethoxy-3a,4-dihydro-3H-indeno[1,2-c]isoxazole analogues Acta Poloniae Pharmaceutica 68(3): 343-348
Ersan, S.; Nacak, S.; Acar, N.; Noyanalpan, N. 1997: Synthesis and antimicrobial activity of 1-dialkylaminomethyl- 2-(p-substituted phenyl)-5-substituted benzimidazole derivatives Arzneimittel-Forschung 47(4): 410-412
Iwaszkiewicz, K.S.; Hua, S. 2014: Development of an effective topical liposomal formulation for localized analgesia and anti-inflammatory actions in the Complete Freund's Adjuvant rodent model of acute inflammatory pain Pain Physician 17(6): E719-E735
Fanelli, O.; Trallori, L.; Mazzoncini, V.; Bianchi, G. 1973: Anti-inflammatory effect of 2-phenyl-5-bromo-indandione (Uridion) with uricosuric acitivity Bollettino Chimico Farmaceutico 112(6): 401-408
Martio, J. 1993: Should the use of anti-inflammatory analgesic drugs be estimated again? Duodecim; Laaketieteellinen Aikakauskirja 109(20): 1795-1802
Brandt, K.D. 1996: Anti-inflammatory and analgesic treatment of osteoarthritis La Revue du Praticien 46(Special Issue 6): S41-S47
Pilli, G.; Erdoğan, H.; Sunal, R. 1993: Some new benzoxazolinone derivatives with analgesic and anti-inflammatory activities Arzneimittel-Forschung 43(12): 1351-1354
Li, M.; Zhou, J.; Fan, Y.; Li, W.; Qin, L.; Yang, W. 1990: Analgesic and anti-inflammatory effects and toxicity of houjianxi Zhongguo Zhong Yao Za Zhi 15(4): 235-238; 256
Li, X.; Chen, H.; Gan, M. 1996: Anti-inflammatory and analgesic effects of scolopendra from different habitats Zhongguo Zhong Yao Za Zhi 21(8): 498-9 512
Mattalia, G.; Marchetti, E. 1971: 2-Aminoalkyl-4,5-diphenyloxazoles with anti-inflammatory and analgesic activities Il Farmaco; Edizione Scientifica 26(6): 512-519