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Inhibition of albumin denaturation and anti-inflammatory activity of acetamido [ (phenyl-4'-yl) -oxymethyl) ]2- (p-substituted phenylamino) -1,2,4-triazoles and -1,3,4-thiadiazoles

Nargund, L.V.; Redd, G.R.; Hariprasad, V.

Indian Journal of Experimental Biology 31(4): 395-396

1993

ISSN/ISBN: 0019-5189
PMID: 8359842
Document Number: 418923
Acetamido [(phenyl-4'-yl)-oxymethyl)]-2-(p-substituted-phenylamino)-1,2,4-tr iazoles (4a-4d) and 1,3,4-thiadiazoles (5a-5d) inhibited the thermal denaturation of bovine serum albumin. As protein denaturation is implicated in inflammation, some compounds which showed good inhibition of denaturation were tested in vivo for anti-inflammatory activity by carrageenan induced edema in the rat paw. Although there was no complete correlation, compounds which showed good inhibition of denaturation also showed significant anti-inflammatory activity.

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