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Synthesis and analgesic activity of new phencyclidine derivatives

al-Deeb, O.A.

Arzneimittel-Forschung 44(10): 1141-1144

1994

ISSN/ISBN: 0004-4172
PMID: 7818589
Document Number: 438717
New phencyclidine derivatives having structural similarities with the well known 4-phenylpiperidine narcotic analgesics were synthesized, characterized and their antinociceptive activity tested in mice by the hot-plate and tail-flick tests. Structure-activity relationships for these compounds further point to the importance of a second aryl moiety at position 4 of the piperidine ring of phencyclidine. In addition, the presence of a hydroxyl group in close proximate to the lipophilic moiety is vital for analgesic activity.

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