Antitumor activity of a piperidine phospholipid
Houlihan, W.J.; Lee, M.L.; Munder, P.G.; Handley, D.A.; Nemecek, G.A.; Jaeggi, C.S.; Winslow, C.W.
Arzneimittel-Forschung 44(12): 1384-1388
1994
ISSN/ISBN: 0004-4172 PMID: 7848363 Document Number: 435577
A piperidine phospholipid ((+-)-2-(hydroxy)((1-octa-decyloxycarbonylpiperidin-3-yl) methoxy-phosphinyl) oxy)-N,N,N,trimethylethaniminium hydroxide inner salt, SDZ 62-826) has been prepared that exhibited weak direct cytotoxicity and strong macrophage-induced cytotoxicity in vitro against a variety of murine and one human tumor cell lines. This compound was found to be as effective as ET-18-OCH-3 and SRI 62-834, phospholipids with both strong direct and macrophage-induced cytotoxicity, in increasing survivors and reducing tumor volume when given either orally or intravenously in the mouse MethA fibrosarcoma model. These findings suggest that the macrophage-induced cytotoxicity exhibited by ET-18-OCH-3 and other phospholipids may play an important role in this tumor model.