Antitumor activity of CPT-11 against rat Walker 256 carcinoma
Furuta, T.; Yokokura, T.; Mutai, M.
Gan to Kagaku Ryoho. Cancer and ChemoTherapy 15(9): 2757-2760
1988
ISSN/ISBN: 0385-0684 PMID: 3415271 Document Number: 320638
The antitumor activity of CPT-11 on rat Walker 256 carcinoma was investigated. Intraperitoneal, intravenous or oral administration of CPT-11 caused a remarkable prolongation of the life span of Wistar rat implanted with Walker 256 intraperitoneally. Intravenous injection and oral administration of CPT-11 markedly inhibited the growth of subcutaneously implanted Walker 256. CPT-11 showed a considerable antitumor activity by continuous intravenous injection against the solid type Walker 256.
Document emailed within 1 workday
Related Documents
Harrison, E.F.; Fuquay, M.E.; Hunter, H.L. 1983: Effect of N-acetylcysteine on the antitumor activity of cyclophosphamide against Walker-256 carcinosarcoma in rats Seminars in Oncology 10(1 Suppl 1: 25-28Lippman, M.M.; Laster, W.R.; Abbott, B.J.; Venditti, J.; Baratta, M. 1975: Antitumor activity of macromomycin B (NSC 170105) against murine leukemias, melanoma, and lung carcinoma Cancer Research 35(4): 939-945
Mazumdar, U.K.; Gupta, M.; Maiti, S.; Mukherjee, D. 1997: Antitumor activity of Hygrophila spinosa on Ehrlich ascites carcinoma and sarcoma-180 induced mice Indian Journal of Experimental Biology 35(5): 473-477
Xiao, C.-W.; Xue, X.-B.; Zhang, H.; Gao, W.; Yu, Y.; Chen, K.; Zheng, J.-W.; Wang, C.-J. 2010: Oncolytic adenovirus-mediated MDA-7/IL-24 overexpression enhances antitumor activity in hepatocellular carcinoma cell lines Hepatobiliary and Pancreatic Diseases International: Hbpd Int 9(6): 615-621
Onishi, T.; Machida, T. 1994: A study on direct antitumor activity of bropirimine (oral interferon inducer) for renal cell carcinoma Hinyokika Kiyo. Acta Urologica Japonica 40(3): 195-200
Kase, S.; Kubota, T.; Furukawa, T.; Watanabe, M.; Teramoto, T.; Ishibiki, K.; Kitajima, M. 1993: Modulation by 1-leucovorin of 5-fluorouracil antitumor activity on human gastric carcinoma xenograft in nude mouse: preliminary report Nihon Geka Gakkai Zasshi 94(6): 659
Otake, N. 1988: The structure and antitumor activity of antitumor antibiotics--recent progress Gan to Kagaku Ryoho. Cancer and ChemoTherapy 15(3): 369-379
Shirasaka, T.; Nakano, K.; Takechi, T.; Satake, H.; Uchida, J.; Fujioka, A.; Saito, H.; Okabe, H.; Oyama, K.; Takeda, S.; Unemi, N.; Fukushima, M. 1996: Antitumor activity of 1 M tegafur-0.4 M 5-chloro-2,4-dihydroxypyridine-1 M potassium oxonate (S-1) against human colon carcinoma orthotopically implanted into nude rats Cancer Research 56(11): 2602-2606
Yamamoto, I.; Takahashi, M.; Suzuki, T.; Seino, H.; Mori, H. 1984: Antitumor effect of seaweeds. IV. Enhancement of antitumor activity by sulfation of a crude fucoidan fraction from Sargassum kjellmanianum Japanese Journal of Experimental Medicine 54(4): 143-151
Kadhim, S.A.; Bowlin, T.L.; Waud, W.R.; Angers, E.G.; Bibeau, L.; DeMuys, J.M.; Bednarski, K.; Cimpoia, A.; Attardo, G. 1997: Potent antitumor activity of a novel nucleoside analogue, BCH-4556 (beta-L-dioxolane-cytidine), in human renal cell carcinoma xenograft tumor models Cancer Research 57(21): 4803-4810
Komiyama, K.; Takeshima, H.; Umezawa, I. 1977: Antitumor activity of a new antitumor antibiotic, sporamycin Gan 68(2): 213-219
Kreitman, R.J.; Puri, R.K.; Pastan, I. 1995: Increased antitumor activity of a circularly permuted interleukin 4-toxin in mice with interleukin 4 receptor-bearing human carcinoma Cancer Research 55(15): 3357-3363
Kase, S.; Kubota, T.; Watanabe, M.; Furukawa, T.; Tanino, H.; Kuo, T.H.; Saikawa, Y.; Teramoto, T.; Kitajima, M. 1995: Recombinant human interferon alpha-2a increases the antitumor activity of 5-fluorouracil on human colon carcinoma xenograft Co-4 without any change in 5-FU pharmacokinetics Anticancer Research 15(1): 153-155
Yamamoto, K.; Mizutani, Y.; Nakanishi, H.; Fujiwara, J.; Ishida, H.; Toiyama, D.; Abe, K.; Hayashi, I.; Okada, K.; Kawauchi, A.; Mizuno, M.; Yoshida, J.; Miki, T. 2008: Significant antitumor activity of cationic multilamellar liposomes containing human interferon-beta gene in combination with 5-fluorouracil against human renal cell carcinoma International Journal of Oncology 33(3): 565-571
Cintra-Gomes, M.C.; Cury, L.; Parreira, M.R.; Elias, C.F.; Areas, M.A. 1990: Effects of Walker 256 carcinoma on metabolic alterations during the evolution of pregnancy Brazilian Journal of Medical and Biological Research 23(9): 909-913
Wenzel, D.G.; Morgan, D.L. 1983: Interactions of ozone and antineoplastic drugs on rat lung fibroblasts and Walker rat carcinoma cells Research Communications in Chemical Pathology and Pharmacology 40(2): 279-287
Grasso, S.; Chimirri, A.; Monforte, P.; Fenech, G.; Zappalà, M. 1986: Compounds with potential antitumor activity. IV. Synthesis and antileukemic activity of 1-aryl-N,N'-di-[2-(1,3,4-thiadiazolyl)]methylenediamine Il Farmaco; Edizione Scientifica 41(9): 713-721
Engers, H.D.; Sorenson, G.D.; Terres, G.; Horvath, C.; Brunner, K.T. 1982: Functional activity in vivo of effector T cell populations. I. Antitumor activity exhibited by allogeneic mixed leukocyte culture cells Journal of Immunology 129(3): 1292-1298
Ulinskaĭte, A.P.; Krauialis, K.I.; Diashrius, A.P. 1989: Activity of 5-alpha- and 5-beta-steroid reductases in subcellular liver structures from rats bearing Walker carcinosarcoma Voprosy Meditsinskoi Khimii 35(1): 77-81
Strigun, L.M.; Chirkova, E.N.; Grigor'eva, G.G.; Gromova, L.A.; Iakunina, M.A. 1989: Biorhythm study of the alpha-glycerophosphate dehydrogenase activity of the peripheral blood lymphocytes in rats with Walker carcinosarcoma Biulleten' Eksperimental'noi Biologii i Meditsiny 107(6): 731-735