Biorhythm study of the alpha-glycerophosphate dehydrogenase activity of the peripheral blood lymphocytes in rats with Walker carcinosarcoma
Strigun, L.M.; Chirkova, E.N.; Grigor'eva, G.G.; Gromova, L.A.; Iakunina, M.A.
Biulleten' Eksperimental'noi Biologii i Meditsiny 107(6): 731-735
1989
ISSN/ISBN: 0365-9615 PMID: 2790174 Document Number: 344790
In the series of experiments alpha-glycerophosphate dehydrogenase activity was daily determined at the same time by cytochemical method in the peripheral lymphocyte of normal rats and those with Walker carcinosarcoma. Using an original algorithm a hierarchy of biorhythms was singled out on a computer according to the individual changes in alpha-glycerophosphate dehydrogenase activity in each rat. It was shown that tumor development resulted in the reduction of the mean level of alpha-glycerophosphate dehydrogenase activity and considerable changes in diverse rhythms. Particular attention is paid to the phase changes, which can reveal changes in phase coordination of glycerophosphate shuttle cycle components.