Studies of physico-chemical properties and structure of aluminum hydrochloride obtained from aluminum isopropanolane
Pawlaczyk, J.; Maciałowicz, A.; Kokot, Z.
Acta Poloniae Pharmaceutica 46(3): 266-271
1989
ISSN/ISBN: 0001-6837 PMID: 2618771 Document Number: 326750
Aluminium hydroxide gels were precipitated from aluminium isopropoxide by addition of water or aqueous solutions of Na2SO4, NaCl and NaNO3. The antacid activity of the gels was assessed on the basis of determinations of their total capacity to neutralize HCl, while structure of the gels was studied by X-ray diffraction analysis and IR spectrometry. It has been stated that prolonged storage, higher storage temperature and presence of water promote conversion of the active form of aluminium hydroxide gels in pharmaceutical preparations into less active forms.