Toxicological properties of benzanthrone and its derivatives in relation to their chemical structure
Volodchenko, V.A.; Sadokha, E.R.; Ostrovskaiai, I.S.; Timoshenko, L.V.
Farmakologiia i Toksikologiia 40(4): 457-463
1977
ISSN/ISBN: 0014-8318 PMID: 902749 Document Number: 120068
The paper presents a comparative study covering toxicological characteristics of benznthrone, brombenzanthrone, dibrombenzanthrone, methoxybenzanthrone, dibenzanronyl, dibenanthrone (violanthrone). The mentioned compounds were found to have a low acute and marked subchronic toxicity manifesting itself in the damaging action on the blood and liver. Here the reaction of the lympho-histiocytic elements along with the appearance of plasmatic and mast cells is typical. In the series of the study compounds most toxic are benzanthrone and its bromine-derivatives. Incorporation of a methoxy-group in the benzanthrone molecule and conjugation of two benzanthrone molecules help lessen the toxic action.