Physico-chemical properties of borate derivatives of DOPA, dopamine, and their liposome forms
Borisova, N.V.; Kriukov, V.I.; Kaplun, A.P.; Shvets, V.I.
Bioorganicheskaia Khimiia 24(11): 848-855
1998
ISSN/ISBN: 0132-3423 PMID: 10079942 Document Number: 484982
To increase the solubility of L-3,4-dihydroxyphenylalanine (DOPA) and dopamine (DA) incorporated in liposomes, it was suggested to convert them into ammonium and 1-adamantylammonium borate complexes. The structure of these complexes was studied by 11B and 1H NMR, IR, and mass spectrometry and conductometry. The liposomic form of the complexes is characterized by a high active compound/lipid molar ratio (0.5). Catechols in the form of complex salts are retained better within the inner volume of liposomes.