Physico-chemical properties of liposome forms of L-3,4-dihydroxyphenylalanine (DOPA) and dopamine
Borisova, N.V.; Kaplun, A.P.; Bogomolov, O.V.; Grigor'ev, V.B.; Iurasov, V.V.; Nikushkin, E.V.; Kryzhanovskiĭ, G.N.; Shvets, V.I.
Bioorganicheskaia Khimiia 22(10-11): 846-851
1996
ISSN/ISBN: 0132-3423 PMID: 9036844 Document Number: 468082
L-3,4-Dihydroxyphenylalanine (DOPA) and dopamine encapsulated in liposomes have been obtained. These preparations can be used as drugs for Parkinson's disease. The level of encapsulation of the compounds under study in liposomes and their partition coefficients have been determined. The kinetics of DOPA (or dopamine) exit from the liposomes have been studied.