Physico-chemical properties of 7-aminodesacetoxycephalosporanic acid
Nys, P.S.; Kol'tsova, E.V.; Shellenberg, N.N.; Savitskaia, E.M.; Levitov, M.M.
Antibiotiki 21(5): 391-394
1976
ISSN/ISBN: 0003-5637 PMID: 1023809 Document Number: 105599
7-Aminodesacetoxycephalosporanic acid (7-ADCA) of 99 per cent purity was prepared by enzymatic hydrolysis of 7-phenylacetamidodesacetoxycephalosporanic acid. Its isoelecti point was determined by the electrophoretic method. Potentiometric titration of zwitterion of 7-ADCA was performed and the constants of its ionization were calculated. Minimum solubility of 7-ADCA zwitterion was determined and the curve of 7-ADCA solubility at wide pH ranges was estimated. Equilibrium of 3 forms of 7-ADCA was estimated.