Synthesis and chemical properties of N- and O-phosphorylated derivatives of creatinol
Ferrari, G.; Casagrande, C.
Arzneimittel-Forschung 29(9a): 1446-1449
1979
ISSN/ISBN: 0004-4172 PMID: 575489 Document Number: 139238
N-Methyl-N-(beta-hydroxyethyl)-guanidine O-phosphate (creatinol O-phosphate) was synthesized from creatinol by phosphorylation with partially hydrolyzed phosphoryl chloride or by dehydration of its phosphate salt. Creatinol N-phosphate was obtained by addition of N-methylamino ethanol to bis-p-nitrobenzylphosphocyanamide, followed by hydrogenolysis. The chemical properties of both compounds were investigated; creatinol N-phosphate was rearranged to creatinol O-phosphate by heating.