Synthesis and biological properties of some 5-aminoorotic acid derivatives
Machoń, Z.; Jasztold-Howorko, R.
Polish Journal of Pharmacology and Pharmacy 33(5): 545-552
1981
ISSN/ISBN: 0301-0244 PMID: 6977766 Document Number: 170989
2,4-Dihydroxy-5-benzoylaminopyrimidine-6-carboxylic acid 1 in the reaction with SOCI2 gave 1-benzoyl-2-oxo-4,6-dihyroxyazetino [3.2-d] pyrimidine 2 which reacted with aliphatic and aromatic amines in ethanol to give appropriate amides 4a-4h of 1 and ethyl 2,4-dihydroxy-5-benzolaminopyrimidine-6-carboxylate 5. Compounds 4d-4g and 8 were centrally active and showed a promising anti-inflammatory and analgesic activity.
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