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Pharmacological studies on new oncostatic acridine derivatives. II. Chronic action

Błaszczyk, B.; Giełdanowski, J.; Patkowski, J.; Kowalczyk-Bronisz, S.H.

Archivum Immunologiae et Therapiae Experimentalis 27(6): 765-776

1979

ISSN/ISBN: 0004-069X
PMID: 549531
Document Number: 153611
Encouraging results of preclinical pharmacologic analysis prompted the following study on the chronic action of N10-oxide 1-nitro-9-/3-dimethylaminopropylamino/-acridine (C-666) and 1-nitro-9-. Toxic action in rabbits and Wistar rats of both compounds on liver, kidneys, gonads and intestine epithelium was observed. These histological changes were not followed by any disorders in functions of liver and gonads. Only administration of compound C-666 was followed by the decrease of filtration of renal glomi. A slight involutional influence of acridine derivatives on lymphopoetic reproductive center of thymus and lymph nodes was observed. There were no disorders of the value of circulating leukocyte system. The investigated compounds had no effect on the system of the red blood cells; only blood clotting time was prolonged. Compounds C-666 and C-829 did not inhibit the growth of tested animals.

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