Synthesis and pharmacological screening of novel 10-substituted diazepino-[2,1-f]-purines
Pawłowski, M.; Drabczyńska, A.; Gorczyca, M.; Malec, D.; Modzelewski, J.
Acta Poloniae Pharmaceutica 51(4-5): 385-391
1994
ISSN/ISBN: 0001-6837 PMID: 7701952 Document Number: 437978
Two series of N10 substituted derivatives of 1,3-dimethyl-2,4,9-trioxo-1,3,6,7,8,10-hexahydro-1,3-diazepino+ ++-[2,1-f]- purine and 1,3-dimethyl-2,4-dioxo-1,3,6,7,8,9-hexahydro-10H-1,3-dizepino- [2,1-f]-purine were synthesized and tested for CNS activity. The most active in central nervous system tests were compounds [II] and [XIV].
Document emailed within 1 workday
Related Documents
Gatta, F.; Zaccari, V.; Huidobro-Toro, J.P.; Chiavarelli, S. 1975: Pyrazino (1,2-a)- and 1,4-diazepino(1,2-a)indoles. II. Synthesis of 1-substituted 10-phenyl-3,4-dihydropyrazino(1,2-a)indoles and of 11-phenyl-4,5-dihydro-4H-diazepino(1,2-a)indoles Il Farmaco; Edizione Scientifica 30(1): 58-69Turło, J.; Zawadowski, T.; Rump, S.; Jakowicz, I.; Gidyńska, T.; Gałecka, E. 1994: Synthesis and pharmacological screening of some N,N'-bis-[4-(4-aryl-1-piperazinyl)butyl]-substituted derivatives of 1,8-dimethylbicyclo-[2.2.2]oct-7-ene-2,3,5,6-tetracarboxydiimide Polish Journal of Pharmacology 46(5): 451-455
Guryn, R.; Szadowska, A.; Pakulska, W. 1994: Diazepinoquinazolines. Part II. Synthesis and pharmacological activity of some derivatives of 1,4-diazepino[2,1-b]quinazoline Acta Poloniae Pharmaceutica 51(6): 483-487
Chernikh, V.P.; Petiunin, G.P.; Krasnovskaia, O.O. 1972: Synthesis and pharmacological activity of substituted amides of pyridinecarboxylic acids Farmatsevtychnyi Zhurnal 27(1): 16-18
Mishra, P.; Joshi, G.K.; Shakya, A.K.; Agrawal, R.K.; Patnaik, G.K. 1992: Pharmacological screening of few new 2-(substituted acetyl) amino-5-alkyl-1,3,4-oxadiazoles Indian Journal of Physiology and Pharmacology 36(4): 247-250
Gutkowska, B.; Wasiak, J. 1984: Synthesis of various 5,5-substituted derivatives of 3-dialkylamino-alkylohydantoin with potential pharmacological activity Acta Poloniae Pharmaceutica 41(3): 307-311
Brancaccio, G.; Lettieri, G.; Monforte, P.; Larizza, A. 1982: Synthesis and pharmacological properties of some 2-substituted dibenz[2,3:6,7]-3a,12b-dihydrooxepin[4,5-d]1,3-dioxolane derivatives Il Farmaco; Edizione Scientifica 37(11): 711-718
Delarge, J. 1976: Synthesis and pharmacological properties of some N-acyl pyridine-3-sulfonamides substituted at position 2 Acta Poloniae Pharmaceutica 33(1): 1-6
Misztal, S.; Boksa, J.; Chojnacka-Wójcik, E.; Tatarczyńska, E.; Lewandowska, A. 1987: Synthesis and pharmacological properties of some 2-substituted 1-(3-pyridyl)-1,2,3,4-tetrahydro-beta-carbolines Polish Journal of Pharmacology and Pharmacy 39(1): 97-103
Graczyk, J.; Kamińska, A.; Szadowska, A.; Tkaczyński, T.; Urbańska, A. 1976: Synthesis and pharmacological properties of some new diphenylacetic acid amides substituted at the nitrogen atom Acta Poloniae Pharmaceutica 33(5): 585-592
Siddiqa, A.; Rehman, A.-U.; Abbasi, M.A.; Siddiqui, S.Z.; Rasool, S.; Sattar, A.; Khan, K.M.; Ahmad, I.; Afzal, S. 2016: Synthesis and antibacterial screening of S-substituted derivatives of 5-(3,4-methylenedioxyphenyl)-1,3,4-oxadiazol-2-thiol Pakistan Journal of Pharmaceutical Sciences 29(1): 27-34
Zabska, R.; Kołodziejczyk, A.; Sieklucka-Dziuba, M.; Morawska, D.; Kleinrok, Z. 1998: Synthesis and pharmacological screening of pyrazolo[3,4-c]pyridazine derivatives Acta Poloniae Pharmaceutica 55(4): 305-310
Mirek, J.; Adamczyk, M.; Chojnacka-Wójcik, E.; Naparzewska, A. 1978: Synthesis and pharmacological screening of some N-carboxymethylbarbituric acid derivatives. i Polish Journal of Pharmacology and Pharmacy 30(5): 685-693
Davidoff, A.N.; Mendelow, B.V. 1993: Substituted purines elicit differential cytokinetic, molecular and phenotypic effects in HL-60 cells Experimental Hematology 21(3): 456-460
Gubert, S.; Braso, M.A.; Sacristán, A.; Ortiz, J.A. 1990: Synthesis and pharmacological screening of new angiotensin converting enzyme inhibitors Farmaco 45(1): 59-79
Nikolova, M.; Fajad, K.; Natova, L. 1993: Synthesis and pharmacological screening of a group of piperazine derivatives. Analgesic activity Farmaco 48(4): 459-472
Di Braccio, M.; Roma, G.; Balbi, A.; Sottofattori, E.; Carazzone, M. 1989: Synthesis and preliminary pharmacological screening of 2,4-disubstituted N,N-dialkyl-1,8-naphthyridine-3-carboxamides Farmaco 44(9): 865-881
Zawadzka, J.; Bogdal, M. 1984: Thiazole derivatives. V. Synthesis and pharmacological screening of amides of 4-phenyl-5-thiazolecarboxylic acids Acta Poloniae Pharmaceutica 41(6): 633-640
Schneider, W.; Schumann, F.; Modjesch, G. 1970: Reaction of substituted piperidones-(4) with malonyl acid dinitrile: way to synthesis of substituted quinuclidines Die Pharmazie 25(12): 724-730
Ersan, S.; Nacak, S.; Acar, N.; Noyanalpan, N. 1997: Synthesis and antimicrobial activity of 1-dialkylaminomethyl- 2-(p-substituted phenyl)-5-substituted benzimidazole derivatives Arzneimittel-Forschung 47(4): 410-412