Synthesis and pharmacological screening of new angiotensin converting enzyme inhibitors
Gubert, S.; Braso, M.A.; Sacristán, A.; Ortiz, J.A.
Farmaco 45(1): 59-79
1990
ISSN/ISBN: 0014-827X PMID: 2186741 Document Number: 350367
We report the preparation of a series of eight L-alanyl-L-proline derivatives and four L-proline derivatives. Their pharmacological activity as anti-hypertensive agents was examined with reference to changes in the contractile response to angiotensin I (AI), bradykinine (BK) and angiotensin II (AII). Compounds 1g, 1h and 2c were the most powerful when compared with known angiotensin-converting inhibitors such as captopril and enalapril, and were selected for further pharmacological study.