Synthesis and pharmacological screening of pyrazolo[3,4-c]pyridazine derivatives
Zabska, R.; Kołodziejczyk, A.; Sieklucka-Dziuba, M.; Morawska, D.; Kleinrok, Z.
Acta Poloniae Pharmaceutica 55(4): 305-310
1998
ISSN/ISBN: 0001-6837 PMID: 9821396 Document Number: 494378
Ethyl 3-chloro-6-(4-chlorophenyl)-pyridazine-4-carboxylate [VII] was cyclized with some nucleophilic reagents (hydrazine hydrate or N-monosubstituted hydrazines) to the new derivatives of pyrazolo[3,4-c]pyridazine [IXa-d]. The structures of the novel compounds were confirmed by elemental and spectral analyses. The effect of several synthesized derivatives on the central nervous system was studied.
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