Synthesis and pharmacological investigations of derivatives 6-azabenzodiazepines
Nawojski, A.; Liszkiewicz, H.; Nawrocka, W.; Ernest, K.; Szymańska-Kosmala, M.
Polish Journal of Pharmacology and Pharmacy 35(1): 77-85
1983
ISSN/ISBN: 0301-0244 PMID: 6684281 Document Number: 206506
Acylated derivatives [2-acetaminomethylene-4-phenyl-1H-tetrahydro-6-azabenzo-1,5-diazepine (4), 2-benzoylaminomethylene (5) and 2-dibenzoylaminomethylene-4-phenyl-1H-tetrahydro-6-azabenzo-1,5-diazepine (6)] of 2-aminomethylene-4-phenyl-1H-tetrahydro-6-azabenzo-1,5-diazepine 3 and carbonyl derivatives [2-formyl-4-phenyl-1H-tetrahydro-6-azabenzo-1,5-diazepine (7), 4-phenyl-1H-tetrahydro-5-azabenzo-1,5-diazepinone-2 (8), 4-phenyl-1H-tetrahydro-6-azabenzo-1,5-diazepinethione-2 (9) and 5-bromo-4-phenyl-1H-tetrahydro-6-azabenzo-1,5-diazepinone-2 (10)] of 6-azabenzo-1,5-diazepines were obtained. They did not display any particular pharmacological activity in screening tests; 2 [8-bromo-2(or 4)-cyano-4(or 2)-phenyl-1H-tetrahydro-6-azabenzo-1-5-diazepine] exerted a weak hypotensive action and 8 possessed negligible anticonvulsant properties in mice.