Synthesis and pharmacological activity of derivatives of exo-trimethylenenorbornane. V
Longobardi, M.; Schenone, P.; Bargagna, A.; Matera, C.; Rossi, F.; Marmo, E.
Il Farmaco; Edizione Scientifica 40(3): 162-169
1985
ISSN/ISBN: 0430-0920 PMID: 4007150 Document Number: 243073
The synthesis of 2 series of amides and glycinamides starting from N-phenyl exo-5,6-trimethylenenorbornan-2-endo-amine, prepared from exo-5,6-trimethylenenorbornan-2-one via NaBH4 reduction of its N-phenyl imine, is described. All amides showed a moderate hypotensive activity in rats, whereas some glycinamides and amides showed weak infiltration anesthesia and antiarrhythmic activity in mice. Effects on heart rate in rats are also reported.
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