Synthesis and pharmacological profile of bicyclo[2.2.2]octane derivatives: N- (1-aryl-4-piperazinyl-butyl) derivatives of 7-isopropyl-6-methyl- and 1-isopropyl-4-methylbicyclo[2.2.2]oct-5-ene-2,3-dicarboxyimide
Zawadowski, T.; Skowron, A.A.; Suski, S.; Rump, S.; Jakowicz, I.
Acta Poloniae Pharmaceutica 52(2): 129-132
1995
ISSN/ISBN: 0001-6837 PMID: 8960243 Document Number: 447446
The new class of compounds characterized by anxiolytic or antidepressive properties, including a number of N-(1-aryl-4-piperazinylbutyl) derivatives of the two isomers: 7-isopropyl-6-methyl- and 1-isopropyl-4-methylbicyclo [2.2.2]oct-5-ene-2,3-dicarboxyimide was synthesized. Two compounds were selected for further pharmacological study.
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