2-methyl-3-acetyl-4-aryl-5-oxo-1,4-dihydro-5H indeno (1,2-b) pyridine derivatives studies and their calcium antagonistic activities
Safak, C.; Simsek, R.; Altas, Y.; Boydag, S.; Erol, K.
Bollettino Chimico Farmaceutico 136(11): 665-669
1997
ISSN/ISBN: 0006-6648 PMID: 9534263 Document Number: 481244
Sixteen 2-methyl-3-acetyl-4-aryl-5-oxo-1,4-dihydro-5H-indeno(1,2-b)pyridine derivatives (3a-p) have been prepared. The structures of the compounds were characterised by IR, 1H-NMR, 13C-NMR, X-Ray and elemental analyses. The calcium antagonistic activity of these compounds were studied in rat taenia coli pre-contracted with 1 mmol/l Ca+2.
Document emailed within 1 workday
Related Documents
Ueda, M.; Masui, M.; Kawakami, M.; Matsunaga, K.; Gemba, T.; Ninomiya, M.; Nakano, A.; Torii, M.; Adachi, I.; Ito, H. 1993: Pharmacological studies on a new dihydrothienopyridine calcium antagonist. 4th communication: prophylactic and therapeutic effects of S-(+)-methyl-4,7-dihydro-3-isobutyl-6-methyl-4-(3-nitrophenyl)thieno[2, 3- b]pyridine-5-carboxylate in stroke-prone spontaneously hypertensive rats Arzneimittel-Forschung 43(12): 1291-1303Nakajima, M.; Adachi, I.; Ueda, M. 1993: Pharmacological studies on a new Dihydrothienopyridine calcium antagonist. 2nd communication: effects of S-(+)-methyl-4,7-dihydro-3-isobutyl-6-methyl-4- (3-nitrophenyl)thieno[2,3-b]pyridine-5-carboxylate on the 1,4-dihydropyridine binding sites in the brain and on isolated arteries in the Cynomolgus monkey Arzneimittel-Forschung 43(12): 1276-1282
Gemba, T.; Ninomiya, M.; Matsunaga, K.; Ueda, M. 1993: Effects of a novel calcium antagonist, S-(+)-methyl-4,7-dihydro-3-isobutyl-6- methyl-4-(3-nitrophenyl)thieno[2,3-b]pyridine-5-carboxylate (S-312-d), on ischemic amino acid release and neuronal injury in stroke-prone spontaneously hypertensive rats Journal of Pharmacology and Experimental Therapeutics 265(1): 463-467
Kazda, S.; Garthoff, B.; Meyer, H.; Schlossmann, K.; Stoepel, K.; Towart, R.; Vater, W.; Wehinger, E. 1980: Pharmacology of a new calcium antagonistic compound, isobutyl methyl 1,4-dihydro-2,6-dimethyl-4(2-nitrophenyl)-3,5-pyridinedicarboxylate (Nisoldipine, Bay k 5552) Arzneimittel-Forschung 30(12): 2144-2162
Pinna, G.A.; Curzu, M.M.; Barlocco, D.; Cignarella, G.; Cavalletti, E.; Germini, M.; Berger, K. 1988: Synthesis and pharmacological study of 5-aryl-6-methyl-4,5-dihydro-pyridazin-3(2H)ones and related 5-aryl-6-methyl-pyridazin-3(2H)ones Il Farmaco; Edizione Scientifica 43(6): 539-549
Bruno, O.; Ranise, A.; Bondavalli, F.; Schenone, P.; D'Amico, M.; Filippelli, A.; Filippelli, W.; Rossi, F. 1993: 3,5-diphenyl-1H-pyrazole derivatives. XI. N-aryl-5(3)-phenyl-4-(3,5- diphenyl-1-pyrazolyl)-3(5)-pyrazole amines, 5-substituted 4,5-dihydro-3-phenyl-4-(3,5-diphenyl-1-pyrazolyl)-1H-pyrazoles and 2,6-disubstituted 1,6-dihydro-4- phenyl-5-(3,5-diphenyl-1-pyrazolyl)pyrimidines with antipyretic, antiinflammatory and other activities Farmaco 48(7): 949-966
Sztanke, K.; Tkaczyński, T. 1997: Synthesis of new derivatives of 3-[4'-(2'-aminothiazolyl)]-8-aryl-7, 8-dihydro-6H-imidazo[2,1-c] [1,2,4]triazin-4-one Acta Poloniae Pharmaceutica 54(3): 223-224
Honda, Y.; Masuda, Y.; Yoshida, T.; Sato, F.; Kurokawa, M.; Hosoki, K. 1995: Studies on calcium antagonistic and alpha 1-adrenergic receptor blocking activities of monatepil maleate, its metabolites and their enantiomers Arzneimittel-Forschung 45(10): 1057-1060
Papageorgiou, A.; Iakovidou, Z.; Mourelatos, D.; Mioglou, E.; Boutis, L.; Kotsis, A.; Kovala-Demertzi, D.; Domopoulou, A.; West, D.X.; Dermetzis, M.A. 1997: Antineoplastic and cytogenetic effects of complexes of Pd (II) with 4N-substituted derivatives of 2-acetyl-pyridine-thiosemicarbazone Anticancer Research 17(1a): 247-251
Zawadowski, T.; Skowron, A.A.; Suski, S.; Rump, S.; Jakowicz, I. 1995: Synthesis and pharmacological profile of bicyclo[2.2.2]octane derivatives: N-(1-aryl-4-piperazinyl-butyl) derivatives of 7-isopropyl-6-methyl- and 1-isopropyl-4-methylbicyclo[2.2.2]oct-5-ene-2,3-dicarboxyimide Acta Poloniae Pharmaceutica 52(2): 129-132
Rudnicka, W.; Foks, H.; Janowiec, M.; Zwolska-Kwiek, Z. 1986: Studies of pyrazine derivatives. XXI. Synthesis and tuberculostatic activity of 4-aryl-1-pyrazinoylthiosemicarbazides and the products of their cyclization to 1,2,4-triazole-3-thione derivatives Acta Poloniae Pharmaceutica 43(6): 523-528
Ikizler, A.A.; Demirbas, A.; Johansson, C.B.; Celik, C.; Serdar, M.; Yuksek, H. 1998: Synthesis and biological activities of some 4,5-dihydro-1H-1,2,4-triazol-5-one derivatives Acta Poloniae Pharmaceutica 55(2): 117-123
Eigenmann, R.; Blaber, L.; Nakamura, K.; Thorens, S.; Haeusler, G. 1981: Tiapamil, a new calcium antagonist. 1. Demonstration of calcium antagonistic activity and related studies Arzneimittel-Forschung 31(9): 1393-1401
Boido, A.; Novelli, F.; Savelli, F.; Sparatore, F.; Russo, S.; Filippelli, W.; Susanna, V.; Marmo, E. 1989: Preparation and pharmacologic activity of amido- derivatives of 3-methyl-3,4-dihydro benzo- and pyrido-1,2,4-triazin-3-acetic acids Farmaco 44(3): 279-301
Zhao, L.Q.; Yang, Z.; Zhang, S.F. 2001: 5,6-diaryl-2,3-dihydro-1-pyrrolizinone derivatives synthesis and antiiflammatory and analgesic activities Yao Xue Xue Bao 36(4): 258-261
Kossakowski, J.; Zawadowski, T.; Kuśmierczyk, J. 1998: Synthesis of new N-[4-(4-aryl- and 4-heteroaryl-1-piperazinyl)butyl]derivatives of 1-methyl-5-oxobicyclo[2.2.1]heptane-2,3-dicarboximide with an expected anxiolytic activity Acta Poloniae Pharmaceutica 55(4): 315-318
Holla, B.S.; Shivananda, M.K.; Akberali, P.M.; Baliga, S.; Safeer, S. 1996: Studies on arylfuran derivatives-Part VI. Synthesis, characterization and antibacterial activities of some 6-(5-aryl-2-furyl)-1,2,4-triazolo [3,4-b]-1,3,4-thiadiazoles and 6-(5-nitro-2-furyl)-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazoles Farmaco 51(12): 785-792
Dymek, W.; Zimon, R. 1972: Studies on pyridine derivatives Acta Poloniae Pharmaceutica 29(3): 243-246
Xin, T.; Ding, J.; Zhang, X.P. 1993: Synthesis and antibacterial activities of 1-amino-6-fluoro-1,4-dihydro-4-oxo-7-(substituted) piperazinyl-3-quinolinecarboxylic acids and their derivatives Yao Xue Xue Bao 28(11): 865-869
Ali, M.A.; Ismail, R.; Choon, T.S.; Yoon, Y.K.; Wei, A.C.; Pandian, S.; Samy, J.G.; De Clercq, E.; Pannecouque, C. 2011: Synthesis and anti-HIV activity of novel 3-substituted phenyl-6,7-dimethoxy-3a,4-dihydro-3H-indeno[1,2-c]isoxazole analogues Acta Poloniae Pharmaceutica 68(3): 343-348