Top Abstract Purchase Related
Home
>
Node
>
Subnode

Preparation and pharmacologic activity of amido- derivatives of 3-methyl-3,4-dihydro benzo- and pyrido-1,2,4-triazin-3-acetic acids

Boido, A.; Novelli, F.; Savelli, F.; Sparatore, F.; Russo, S.; Filippelli, W.; Susanna, V.; Marmo, E.

Farmaco 44(3): 279-301

1989

ISSN/ISBN: 0014-827X
PMID: 2789056
Document Number: 329219
Thirteen amidoderivatives of 3-methyl-3,4-dihydro-6-R-benzo-1,2,4-triazin-3-yl-acetic acids and of 3-methyl-3,4-dihydro-pyrido [3,2-e]/[3,4-e]-1,2,4-triazin- 3-yl-acetic acids were prepared and submitted to a wide pharmacological screening. The dihydrobenzotriazine and dihydropyridotriazine moieties were endowed with a wide pharmacogenic capacity; in fact, several compounds exhibited high antiinflammatory [(I c), (I d), (II d), (V f), (VI f)], diuretic [(I f), (I g), (I h)] and antihypertensive activities [(I d), (III d)], as well as minor effects on the C.N.S.

Document emailed within 1 workday
Secure & encrypted payments

Sztanke, K.; Tkaczyński, T. 1997: Synthesis of new derivatives of 3-[4'-(2'-aminothiazolyl)]-8-aryl-7, 8-dihydro-6H-imidazo[2,1-c] [1,2,4]triazin-4-one Acta Poloniae Pharmaceutica 54(3): 223-224
Moron, J.; Rautureau, M.; Huel, C.; Pierré, A.; Berthier, L.K.; Atassi, G.; Bisagni, E. 1993: Synthesis and evaluation of 4-amino-substituted 7-methoxy (and 7-hydroxy)- 11-methyl (and 5,11-dimethyl)-10H-pyrido [2,3-b] carbazoles and 4-amino- substituted 11-methyl (and 5,11-dimethyl)-10H-pyrido[3',4':4,5] pyrrolo [3,2-g] quinolines, two new series related to antitumor ellipticine derivatives Anti-Cancer Drug Design 8(6): 399-416
Mosti, L.; Menozzi, G.; Schenone, P.; Dorigo, P.; Gaion, R.M.; Belluco, P. 1992: Synthesis and cardiotonic activity of 2-substituted 5-cyano-1,6-dihydro-6-oxo-3-pyridinecarboxylic acids and their methyl or ethyl esters Farmaco 47(4): 427-437
Bellini, A.; Quaglio, M.P.; Guarneri, M.; Cavazzini, G. 1986: Antibacterial activity of cholane compounds: amido and amino derivatives (VI) Bollettino Chimico Farmaceutico 125(9): 362-365
Bianco, T.; Centore, R.; Giannetti, P.; Scuri, R. 1992: Compared kinetics of 2-(2,3-dihydro-5-acetoxy-4,6,7-trimethylbenzofuranyl) acetic acid (IRFI 016) and its active metabolite 2-(2,3-dihydro-5-hydroxy-4,6,7-trimethylbenzofuranyl) acetic acid (IRFI 005) in plasma and bronchial alveolar liquid in mice Drugs under Experimental and Clinical Research 18(3): 93-97
Ombetta, J.E.; Lyet, S.; Xicluna, A.; Robert, J.F.; Panouse, J.J. 1988: Preparation and pharmacologic approach of a series of dihydro-4,5 thieno(2,3-c)quinoline-4-ones Annales Pharmaceutiques Francaises 46(6): 377-389
Sugawara, T.; Yoshida, M.; Shimoda, K.; Takada, S.; Miyamoto, M.; Nomura, M.; Kato, M. 1996: One-month oral toxicity study of the new quinolone antibacterial agent (S)-10-[(S)-(8-amino-6-azaspiro[3,4]octan-6-yl)-9-fluoro-2,3-dihydro-3- methyl-7-oxo-7H-pyrido [1,2,3-de] [1,4] benzoxazine-6-carboxylic acid hemihydrate in rats and cynomolgus monkeys Arzneimittel-Forschung 46(7): 705-710
Guo, H.Y.; Sun, L.Y.; Tang, Y.; Yan, G.H.; Zhang, Z.P. 1988: Studies on pyridonecarboxylic acids as antibacterial agents. VI. Synthesis and antibacterial activity of 7-chloro-6-fluoro-1-ethyt-1, 4-dihydro-4-oxopyrido(2,3-c)pyridazine-3-carboxylic acid and derivatives Yao Xue Xue Bao 23(8): 566-573
Maczyński, M.; Jezierska, A.; Zimecki, M.ł; Ryng, S.ła. 2003: Synthesis, immunological activity and theoretical study of new 5-substituted 3-methylisoxazole[5,4-d] 1,2,3-triazin-4-one derivatives Acta Poloniae Pharmaceutica 60(2): 147-150
Safak, C.; Simsek, R.; Altas, Y.; Boydag, S.; Erol, K. 1997: 2-methyl-3-acetyl-4-aryl-5-oxo-1,4-dihydro-5H indeno(1,2-b) pyridine derivatives studies and their calcium antagonistic activities Bollettino Chimico Farmaceutico 136(11): 665-669
Lehotai, L.; Morvay, J. 1980: Gas chromatographic determination of acetic, propionic, butyric and valeric acids without the formation of derivatives Acta Pharmaceutica Hungarica 50(1): 21-24
Prakash, L.; Shaihla; Malik, S.; Mital, R.L. 1989: Synthesis and antibacterial activity of some new pyrido[2,3-d]pyrimidine derivatives Die Pharmazie 44(7): 490
Pitrè, D.; Fumagalli, L.; Lorenzotti, E. 1972: Radiological contrast media. XXI. Iodine derivatives of aryl-(3-(N-alkylacylamino) phenoxy) acetic acids Il Farmaco; Edizione Scientifica 27(5): 408-418
Kwapiszewski, W.; Borkowski, L. 1987: Amino acid derivatives of 2-(p-chlorophenoxy)-2-methylpropionic acid as compounds with potential antilipemic agents. II. Preparation of methyl esters of N-[2-(p-chlorophenoxy)-2-methylpropionyl] amino acids Acta Poloniae Pharmaceutica 44(2): 121-131
Xin, T.; Ding, J.; Zhang, X.P. 1993: Synthesis and antibacterial activities of 1-amino-6-fluoro-1,4-dihydro-4-oxo-7-(substituted) piperazinyl-3-quinolinecarboxylic acids and their derivatives Yao Xue Xue Bao 28(11): 865-869
Tylińska, B.; Jasztold-Howorko, R.; Mastalarz, H.; Szczaurska-Nowak, K.; Materek, P.; Wietrzyk, J. 2011: Synthesis of new 1-phenyl-6H-pyrido[4,3-b]carbazole derivatives with potential cytostatic activity Acta Poloniae Pharmaceutica 68(1): 31-37
Fayed, A.A.; Amr, A.E.-G.E.; Al-Omar, M.A.; Mostafa, E.E. 2014: Synthesis and antimicrobial activity of some new substituted pyrido[3',2':4,5]thieno[3,2-d]-pyrimidinone derivatives Bioorganicheskaia Khimiia 40(3): 335-340
Liszkiewicz, H.; Nawrocka, W.P.; Sztuba, B.; Wietrzyk, J.; Jaroszewicz, J.; Nasulewicz, A.; Pełczyńska, M. 2011: Synthesis and antiproliferative activity in vitro of new pyrido[1,4-b]diazepine derivatives and imidazo[4,5-b]pyridine Acta Poloniae Pharmaceutica 68(3): 349-355
Di Braccio, M.; Roma, G.; Mazzei, M.; Balbi, A.; Schiantarelli, P.; Cadel, S.; Bongrani, S. 1988: Derivatives of pyrimidine 1,2-condensate. IV. Synthesis and pharmacological properties of the N,N-disubstituted 4-amino-2H-pyrido(1,2-a)pyrimidin- 2-ones and 2-amino-4H-pyrido(1,2-a)pyrmidin-4-ones Il Farmaco; Edizione Scientifica 43(9): 705-723
Adak, M.; Gupta, J.K. 2006: Hypolipidemic activity of Indan--1--acetic acids Nepal Medical College Journal: Nmcj 8(1): 22-26