Preparation and pharmacologic approach of a series of dihydro-4,5 thieno (2,3-c) quinoline-4-ones
Ombetta, J.E.; Lyet, S.; Xicluna, A.; Robert, J.F.; Panouse, J.J.
Annales Pharmaceutiques Francaises 46(6): 377-389
1988
ISSN/ISBN: 0003-4509 PMID: 2855819 Document Number: 321997
The reaction of ethyl thioglycolate with ortho aminochalcones leads to 2-aryl-l, 2, 4, 5-tetrahydrothieno [2,3-c] quinoline-4-ones or 2-aryl dihydrothienoquinolinones. The deshydrogenation by chloranil or bromine arises the formation of 2-aryl-4,5-dihydrothieno [2,3-c] quinoline-4-ones or 2-aryl thienoquinolinones. These differents compounds do not have any antalgic activity like antipyretic type, the opposite to some thienoquinolines or thienocoumarines. The 2-phenyl dihydrothienoquinolinone has a light hypocholesterolemic activity and his deshydrogenated derivative has a discert platelet agregation inhibition. The absence of substitution on the thienyl cycle takes off any activity.