Top Abstract Purchase Related
Home
>
Node
>
Subnode

Preparation and pharmacological activities of spiro[3,4-dihydro-6/7-R-1,2,4-benzotriazine-3,4'- (1'-substituted) piperi dines

Novelli, F.; Sparatore, F.

Farmaco 51(8-9): 541-550

1996

ISSN/ISBN: 0014-827X
PMID: 8930107
Document Number: 455626
A set of spiro[3,4-dihydro-1,2,4-benzotriazines-3,4'-piperidine] derivatives was prepared and subjected to a broad pharmacological screening. Many of these compounds are characterized by a 3-(4-fluorobenzoyl)propyl substituent on the piperidine nitrogen, thus resembling the p-fluorobutyrophenone antipsychotics. Modest dopamine antagonism was observed for the tested compounds, which however were mainly endowed with analgesic and antihypertensive activities. Antihypercholesterolemic activity was also seen in compound 5, which represents an interesting new lead, being completely structurally unrelated to the known agents in this field.

Document emailed within 1 workday
Secure & encrypted payments

Kosikowska, U.; Siwek, A.; Dobosz, M. 2006: Antimicrobial activities of 4-substituted-3-(piperidin-4-yl)-4,5-dihydro-1H-1,2,4-triazole-5-thiones Acta Poloniae Pharmaceutica 63(5): 460-463
Xin, T.; Ding, J.; Zhang, X.P. 1993: Synthesis and antibacterial activities of 1-amino-6-fluoro-1,4-dihydro-4-oxo-7-(substituted) piperazinyl-3-quinolinecarboxylic acids and their derivatives Yao Xue Xue Bao 28(11): 865-869
Carboni, S.; Da Settimo, A.; Bertini, D.; Ferrarini, P.L.; Livi, O.; Tonetti, I. 1975: Preparation and pharmacological study of some N-substituted amino-1,8-naphthyridines Il Farmaco; Edizione Scientifica 30(3): 185-196
Bruno, O.; Ranise, A.; Bondavalli, F.; Schenone, P.; D'Amico, M.; Filippelli, A.; Filippelli, W.; Rossi, F. 1993: 3,5-diphenyl-1H-pyrazole derivatives. XI. N-aryl-5(3)-phenyl-4-(3,5- diphenyl-1-pyrazolyl)-3(5)-pyrazole amines, 5-substituted 4,5-dihydro-3-phenyl-4-(3,5-diphenyl-1-pyrazolyl)-1H-pyrazoles and 2,6-disubstituted 1,6-dihydro-4- phenyl-5-(3,5-diphenyl-1-pyrazolyl)pyrimidines with antipyretic, antiinflammatory and other activities Farmaco 48(7): 949-966
Subudhi, B.B.; Panda, P.K.; Swain, S.P.; Sarangi, P. 2009: Synthesis, characterization and anticonvulsant activity evaluation of some 1,4-dihydropyridines and 3,5-(substituted)oxycarbonyl-1,4-dihydro-2,6-dimethyl-N-[2-(4-sulfamoylphenylamino)-acetyl]-4-(substituted)pyridines Acta Poloniae Pharmaceutica 66(2): 147-153
Sandberg, R.; Domeij, K.E.; Stening, G.; Svensson, S.; Willman, N.; Akerman, B. 1980: N-aminoalkylsuccinimides as local anaesthetics. II. 1,2,3,4-Tetrahydronaphthalene-1-spiro-3'-pyrrolidine-2',5'-diones substituted in the aromatic nucleus Acta Pharmaceutica Suecica 17(4): 169-176
Gronowitz, S.; Svensson, L.; Stjernström, N.; Ogren, S.O. 1979: Thiophene-containing potentially neuroleptic rigid spiroamines. II. Synthesis of some N,N-dimethylamino-substituted spiro[H-cyclohepta[2,1-b;4,5-b]dithiophene-9,1'-cycloalkanes Acta Pharmaceutica Suecica 16(6): 365-375
El-Telbany, F.A.; Ghoneim, K.M.; Khalifa, M. 1976: Synthesis of certain spiro compounds for pharmacological study. Part Ii Journal de Pharmacie de Belgique 31(4): 403-410
Srivastava, V.K.; Singh, S.; Palit, G.; Shanker, K. 1986: 1-[4-(4,5-dihydro-1H-imidazol-2-yl)aminophenyl]-3-(substituted phenyl)-2-propene-1-one as antiparkinsonian agents Die Pharmazie 41(8): 598-599
Davidenko, T.I.; Bondarenko, G.I. 1990: Reduction of nitro-substituted 1,2-dihydro-3H-1,4-benzodiazepine- 2-ones by E. coli cells immobilized in carrageenan Prikladnaia Biokhimiia i Mikrobiologiia 26(3): 349-354
Islam, M.; Siddiqui, A.A. 2010: Synthesis, antituberculostatic, antifungal and antibacterial activities of 3-substituted phenyl-6-substituted phenyl-1,2,4-triazolo[4,3-b]pyridazines Acta Poloniae Pharmaceutica 67(5): 555-562
Ali, M.A.; Ismail, R.; Choon, T.S.; Yoon, Y.K.; Wei, A.C.; Pandian, S.; Samy, J.G.; De Clercq, E.; Pannecouque, C. 2011: Synthesis and anti-HIV activity of novel 3-substituted phenyl-6,7-dimethoxy-3a,4-dihydro-3H-indeno[1,2-c]isoxazole analogues Acta Poloniae Pharmaceutica 68(3): 343-348
Mosti, L.; Menozzi, G.; Schenone, P.; Dorigo, P.; Gaion, R.M.; Belluco, P. 1992: Synthesis and cardiotonic activity of 2-substituted 5-cyano-1,6-dihydro-6-oxo-3-pyridinecarboxylic acids and their methyl or ethyl esters Farmaco 47(4): 427-437
Obniska, J.; Pawłowski, M.; Kołaczkowski, M.; Czopek, A.; Duszyńska, B.; Klodzińska, A.; Tatarczyńska, E.; Chojnacka-Wójcik, E. 2003: Synthesis and 5-HT1A/5-HT2A receptor activity of new N-[3-(4-phenylpiperazin-1-yl)-propyl] derivatives of 3-spiro-cyclohexanepyrrolidine-2,5-dione and 3-spiro-beta-tetralonepyrrolidine-2,5-dione Polish Journal of Pharmacology 55(4): 553-557
Yan, L.; Xu, B.; Ma, Z.; Zhu, Y.; Yang, Q. 1998: Synthesis and antibacterial activity of 7-substituted-1-ethyl(2-fluoro-ethyl)-6,8-difluoro-1,4-dihydro-4- oxoquinoline-3-carboxylic acid Yao Xue Xue Bao 33(5): 392-395
Ikizler, A.A.; Demirbas, A.; Johansson, C.B.; Celik, C.; Serdar, M.; Yuksek, H. 1998: Synthesis and biological activities of some 4,5-dihydro-1H-1,2,4-triazol-5-one derivatives Acta Poloniae Pharmaceutica 55(2): 117-123
Gogerty, J.H.; Penberthy, C.; Iorio, L.C.; Trapold, J.H. 1975: Pharmacological analysis of a new anorexic substance: 5-hydroxy-5(4'-chlorophenyl)-2, 3-dihydro-5H-imidazo-(2, 1-a) isoindole (Mazindol) Archives Internationales de Pharmacodynamie et de Therapie 214(2): 285-307
Ombetta, J.E.; Lyet, S.; Xicluna, A.; Robert, J.F.; Panouse, J.J. 1988: Preparation and pharmacologic approach of a series of dihydro-4,5 thieno(2,3-c)quinoline-4-ones Annales Pharmaceutiques Francaises 46(6): 377-389
Zhao, L.Q.; Yang, Z.; Zhang, S.F. 2001: 5,6-diaryl-2,3-dihydro-1-pyrrolizinone derivatives synthesis and antiiflammatory and analgesic activities Yao Xue Xue Bao 36(4): 258-261
Zhang, X.P.; Zhang, X.J.; Zheng, X.H.; Chen, L.; Dai, Z.R. 1980: Studies on antimalarials. I. Synthesis and antimalarial activities of some derivatives of 2,4-diamino-5-substituted amino pyrimidines and 2,4-diamino-6-methyl-5-substituted amino pyrimidines Yao Xue Xue Bao 15(12): 711-718