Synthesis and pharmacological properties of a series of 2-piperidino alkanol derivatives
Carron, C.; Jullien, A.; Bucher, B.
Arzneimittel-Forschung 21(12): 1992-1998
1971
ISSN/ISBN: 0004-4172 PMID: 4400568 Document Number: 5820
The synthesis of some 2-piperidino alkanol derivatives is described. Their pharmacological study displays prevailing a-adrenergic blocking and vasodilator effects as spasmolytic and antiarrhythmic activities. Among them the 2- (4-benzyl-piperidino)-1-(4-hydroxypheny1)-1-propanol is selected for its intense peripheral and cerebral vasodilator effect, superior to isoxsuprine. A tentative interpretation is given for the mechanism of action as well as for the structural relationships necessary for the activity, arguing from the differences observed in the series
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