Derivatives of 2-mercaptobenzenesulphonamide. XVII. Synthesis and some pharmacological properties of 1-[4-R-5-cyano-2-dialkylaminoalkylthio) benzenesulphonyl]-2-imidiazolidi none hydrochlorides
Pomarnacka, E.; Brzozowski, Z.; Gajewski, F.; Filczewski, M.; Oledzka, K.; Kosmala, M.; Sliwoska, M.
Acta Poloniae Pharmaceutica 51(4-5): 393-401
1994
ISSN/ISBN: 0001-6837 PMID: 7701953 Document Number: 434587
Syntheses of 1-[4-R-5-cyano-2-(dialkylaminoalkylthio)-benzenesulphonyl]- 2-imidiazolidinones [IIIa-h,IVa-m] and their hydrochlorides [Va-h, VIa-m] are described herein. The results of preliminary pharmacological examinations, such as acute toxicity and influence on the circulatory system are presented. Some structure-activity relationship are also discussed.
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