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Pharmacological screening of few new 2- (substituted acetyl) amino-5-alkyl-1,3,4-oxadiazoles

Mishra, P.; Joshi, G.K.; Shakya, A.K.; Agrawal, R.K.; Patnaik, G.K.

Indian Journal of Physiology and Pharmacology 36(4): 247-250

1992

ISSN/ISBN: 0019-5499
PMID: 1291476
Document Number: 403084
Nine new 2-(substituted acetyl) amino-5-alkyl-1,3,4-oxadiazoles were synthesised and confirmed on the basis of IR and nitrogen analysis. These were screened for spasmolytic, anti-inflammatory and their effects on blood pressure after determining ALD50. Compounds GK-4 i.e. 2-(diethylaminoacetyl)- amino-5-methyl-1,3,4-oxadiazole and GK-8 i.e. 2-(din-propylamino acetyl)-amino-5-ethyl-1,3,4-oxadiazole were found to be spasmolytic. Compound GK-6 i.e. 2-(diethylaminoacetyl)-amino-5-n-propyl-1,3,4-oxadiazole was found to be a potent hypotensive agent with the effect lasting for more than two hours.

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