QSAR study on 1-benzyl-4[w (substituted phthalimido) alkyl]piperidines:acetyl cholinesterase inhibitors
Srivastava, A.K.; Khare, A.; Agrawal, S.; Srivastava, P.
Indian Journal of Biochemistry and Biophysics 35(6): 393-396
1998
ISSN/ISBN: 0301-1208 PMID: 10412237 Document Number: 492308
QSAR studies on a series of 18 piperidine derivatives, which act as acetyl cholinesterase (AchE) inhibitors, have been performed using van der Waals volume (V omega) and topochemical index (tau). Significant correlations have been obtained, which make it clear that AchE inhibition activity is controlled dominantly by topo chemical index.
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