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Antiallergic activity of alkyl substituted pyrazolo[3, 4-d]pyrimidine (compound 88-765)

Gupta, P.P.; Srimal, R.C.; Avasthi, K.; Garg, N.; Chandra, T.; Bhakuni, D.S.

Indian Journal of Experimental Biology 33(1): 38-40

1995

ISSN/ISBN: 0019-5189
PMID: 9135673
Document Number: 443502
Compound 88-765 (4-amino-6-methylthio-1-(2', 2'-diethoxyethyl)-1 H-pyrazolo[3, 4-d]pyrimidine) has shown potent antiallergic activity in experimental models. The compound inhibited the passive cutaneous anaphylaxis (PCA) reaction in rats in dose-dependent manner (5-100 mg/kg, po) by 47 to 87%. In mice it inhibited PCA by 78% at 50 mg/kg, po. It also inhibited mast cell degranulation of normal and passively sensitised rats induced by compound 48/80 and egg albumin, respectively. These effects of Compound 88-765 were comparable with that of disodium cromoglycate (DSCG). The results suggest that compound 88-765 possesses potent antiallergic activity.

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