Triphasic dose-lethality relationships for amphetamine and certain ring-substituted amphetamines in isolated or aggregated mice
Davis, W.M.; Waters, I.W.; Hatoum, H.T.; Buelke, J.L.; Braude, M.C.
Research Communications in Chemical Pathology and Pharmacology 17(4): 575-582
1977
ISSN/ISBN: 0034-5164 PMID: 578333 Document Number: 591
Dose-mortality curves were traced in Swiss-Webster albino mice under isolated and aggregated (N = 5/group) conditions after i.p. injections of d-amphetamine (AMP), dl-4-methoxyamphetamine (PMA), dl-2,5-dimethoxyamphetamine, dl-2,5-dimethoxy-4-bromoamphetamine (DOB), dl-2,5-dimethoxy-4-methylamphetamine (DOM), dl-3,4-methylenedioxyamphetamine (MDA), dl-2-methoxy-4,5-methylenedioxyamphetamine (MMDA-2) and dl-2,4,5-trimethoxyamphetamine (TMA-2). Only PMA, DOM and TMA-2 did not show a triphasic dose-lethality relationship under aggregated or isolated conditions. Only for AMP, MDA and TMA-2 did responses of isolated and aggregated mice differ. Either of the 2 unusual AMP properties regarding lethality in mice, enhancement by aggregation and the triphasic pattern, was found for certain methoxyamphetamines without the other. These 2 properties evidently are not derived from a common mechanism.
Document emailed within 1 workday
