Efficacy of various pretreatment and therapy regimens against soman lethality in mice

Patocka, J.; Jakl, A.; Bajgar, J.; Fusek, J.

Sbornik Vedeckych Praci Lekarske Fakulty Karlovy University V Hradci Kralove 34(3): 243-247

1991


ISSN/ISBN: 0049-5514
PMID: 1788521
Document Number: 385176
The efficacy of a number of drug pretreatment combinations in protecting mice against lethal effects of soman was determined. Pyridostigmine peroral pretreatment followed by intramuscular postpoisoning therapy with atropine, obidoxime and/or trimedoxime, and diazepam protected mice against the lethal action of soman. Combination of pyridostigmine with trihexyphenidyl, benactyzine and bis-(4-hydroxyiminomethyl) pyridinium-methane dichloride improved prophylactic action even further.

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