The effect of insulin on lethality in mice with acute ethanol poisoning
Savitskaia, E.V.; Listvina, V.P.; Zabirova, I.G.
Patologicheskaia Fiziologiia i Eksperimental'naia Terapiia 1: 47-48
1990
ISSN/ISBN: 0031-2991 PMID: 2191256 Document Number: 361861
Intraperitoneal injection of 25% ethanol solution in LD80 doses caused death of approximately 60% of satiated and starving animals in the first 60 minutes. The death peak was encountered 3-10 minutes after the injection of ethanol and corresponded with the peak of its concentration in the blood. The early death of the animals was connected with arrest of respiration in inhibition of cardiac activity. A tendency towards increase of ethanol LD50 60 minutes after its injection in administration of insulin was encountered. The changes of ethanol LD50 were statistically insignificant.