Effect of exogenous superoxide dismutase and 1,4-diazobicyclo- (2,2,2,) -octane on the resistance of mice to acute oxygen poisoning
Gerasimov, A.M.; Gusev, V.A.; Brusov, O.S.
Biulleten' Eksperimental'noi Biologii i Meditsiny 83(2): 147-150
1977
ISSN/ISBN: 0365-9615 PMID: 851614 Document Number: 121854
Single injection to mice of a perified preparation of superoxide dismutase (1000 units, intravenously) combined with catalase (0.5 mg) or without it failed to protect from the toxic action of 100% oxygen under the pressure of 5 ata. 1,4-diazobicyclo (2.2.2) octane (6 mg, intraperitoneally) increased the preconvulsive survival period of mice under these conditions. The formation of single oxygen under hyperoxia in vivo is supposed.
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