Effect of ethanol administration on hepatic ethanol and drug-metabolizing enzymes and on rates of ethanol degradation
Tobon, F.; Mezey, E.
Journal of Laboratory and Clinical Medicine 77(1): 110-121
1971
ISSN/ISBN: 0022-2143 PMID: 5540420 Document Number: 37805
Male rats were given ethanol for 24, 48 and 72 h, 7 and 14 days. Whereas liver weights and the cytosol enzymes alcohol dehydrogenase and lactate dehydrogenase were not changed, significant increases were obtained as early as 24 h after ethanol was given for microsomal ethanol-oxidising activity and at 48 h for aniline hydroxylase and cytochrome P-450. Microsomal protein concentration was increased only at 14 days.
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